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Importantly, these findings demonstrate that while the depletion of glutamate by GCLC is a metabolic vulnerability under nutrient replete conditions, we find that it confers an advantage under cysteine starved conditions

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97 Notably, GPX4 expression did not significantly affect TGF-1-induced EMT in A549 cells, nor did it reverse erastin-induced ferroptosis

The mice were maintained in an SPF room with ad libitum access to water on a 12-h light/dark cycle